Dimitrios Vavylonis

Our group develops theoretical models describing the role of the actin cytoskeleton in cell organization and function. Networks and bundles of actin filaments spontaneously form subcellular structures with mechanical integrity that provide cells with shape, generate mechanical forces and movement by polymerization, and act as tracks for motor proteins. In collaboration with biologists and computer scientists, we use the methods of physics to study, analyze, and model the physical properties of these adaptive biological materials. Their plasticity underlies the function of the actomyosin contractile ring during cytokinesis and cell polarization for directional cell motion and growth.