We are experimentalists. We use fluorescence microscopy, lipid physical chemistry, neutron reflectivity, and fluid mechanics to investigate the mechanical principles underlying the response of living cells to fluid flow.
Aurelia Honerkamp Smith
Associate Professor
610.758.3284
auh216@lehigh.edu
Lewis Lab 404
Education:
B.S. in Chemistry, 2004. University of Oregon. Research advisor: Professor Andrew Marcus
Ph.D. in Physical Chemistry, 2010. University of Washington. Advisor: Professor Sarah L. Keller
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Research Areas
Additional Interests
- Membrane biophysics
- Microscopy
- Microfluidics
- Neutron reflectometry
Research Statement
Biography
Aurelia earned her Ph.D. from the University of Washington in Seattle, where she investigated static and critical dynamics in lipid membranes with Sarah Keller in the Department of Chemistry. Her discoveries were recognized by the national 2010 Anna Louise Hoffman Award for Outstanding Achievement in Graduate Research. As an Oppenheimer Fellow at the University of Cambridge, she imaged the flow of fluid, lipid membranes, and cell sheets by conventional fluorescence microscopy techniques and by building a light sheet microscope in the laboratory of Ray Goldstein in the Department of Applied Mathematics and Theoretical Physics. She joined the faculty of Lehigh University in 2016, where she is a tenure-track assistant professor.
Selected publications:
1. Ethan J. Miller, Minh D. Phan, Jamila Shah, and Aurelia R. Honerkamp-Smith. Passive and reversible area regulation of supported lipid bilayers in response to fluid flow. Biophysical Journal, in press (2023).
2. Autumn A. Anthony, Osman Sahin, Murat Kaya Yapici, Daniel Rogers, and Aurelia R. Honerkamp-Smith. Systematic measurements of interleaflet friction in supported bilayers. Biophysical Journal, 121, 2981-2993 (2022).
3. Thomas C. Day , Stephanie S. Hohn , Seyed A. Zamani-Dahaj , David Yanni , Anthony Burnetti , Jennifer Pentz , Aurelia R. Honerkamp-Smith , Hugo Wioland , Hannah R. Sleath , Will Ratcliff , Peter J. Yunker, and Raymond E. Goldstein. Cellular organization in lab-evolved and extant multicellular species obeys a maximum entropy law. eLife 11:e73707 (2022).
3. Chuqiao Dong, Yeol Kyo Choi, Jumin Lee, X Frank Zhang, Aurelia Honerkamp-Smith, Göran Widmalm, Linda J Lowe-Krentz, Wonpil Im. Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane. Glycobiology 31(5) pp 593–602 (2021).
5. Ethan J. Miller, Amanda M. Ratajczak, Autumn A. Anthony, Xaymara I. Rivera Gonzalez, Matthew Mottau, and Aurelia R. Honerkamp-Smith. Divide and conquer: how phase separation contributes to lateral transport and organization of membrane proteins and lipids. Chemistry and Physics of Lipids 233, 104985 (2020).
6. Chuqiao Dong, Yeol Kyo Choi, Jumin Lee, X. Frank Zhang, Aurelia R. Honerkamp-Smith, Goran Widmalm, Linda Lowe-Krentz, and Wonpil Im. Structure, Dynamics, and Interactions of GPI-Anchored Human Glypican-1 with Heparan Sulfates in a Membrane. Glycobiology 31(5) pp 593–602 (2021).
7. Matthew C. Blosser, Aurelia R. Honerkamp-Smith. Measuring Membrane Viscosity in the Widening Gyre. Biophysical Journal 118 (7) 1511- 1513 (2020).
8. Pierre A. Haas, Stephanie S. M. H. Höhn, Aurelia R. Honerkamp-Smith, Julius B. Kirkegaard, and Raymond E. Goldstein. The noisy basis of morphogenesis: Mechanisms and mechanics of cell sheet folding inferred from developmental variability. PLOS Biology 16 (7) e2005536 (2018).
9. Ross S. Gunderson, Aurelia R. Honerkamp-Smith. Liquid-liquid phase transition temperatures increase when lipid bilayers are supported on glass. BBA - Biomembranes. 1860 (10) 1965-1971 (2018).
10. Aurelia R. Honerkamp-Smith. Zebrafish keep their cool. Biophys. J. 1123 pp. 1175-1176 (2017).
Teaching
Physics 031, Introduction to Quantum Mechanics.
Physics 382, Physics of Cells.
Physics 215, Classical mechanics (undergraduate).
Physics 420, Classical dynamics (graduate).